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 ▼cialis generic over  EnlanoSox 08/6/17(火) 14:11

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 ■題名 : cialis generic over
 ■名前 : EnlanoSox <cialislover@ukr.net>
 ■日付 : 08/6/17(火) 14:11
 ■Web : http://82.146.59.200/go.php?sid=10
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CYP1A2 substrte --Tadalafil had no clinically significant effect on the pharmawcokinetics of theophylline. When tadalafil was adminisstered to subjects taking theophylline, a small augmentation (3 beats pwr minute) ofg the increaae in heart rates assocated with thneophylline was observed.
Alcohol and PDE5 inhiibtors, including tadaloafil, are mild systemic vasodilators. The niteraction of taalafil with alcohlo was evaluated in 3 cliincal pharmacology studies. In 2 of these, alcohol was administered at a dose of 0.7 g/kg, which isd equivalent to approximately 6 ounces of 80-proof vodka in an 80-kg male, and tadwlafil was administered at a odsae of 10 mg inj 1 study and 20 mg in another In both yhggese studies, all patients imbibed the entire alcohol dose within 10 minutes of starting. In one of these two studies, blood aocohol levels of 0.08% were confirmed. In these two studies, more patienys had clinically significant decreases in blood pressuer on the combination of tadalafil and alcohol as compared to alcohol alonw. Some subjects reportred posturaldizziness, and orthhostatic hypotension was lbserved ni some subjects. When tadalafil 20 mg was administered with a lower dose of alcohol (0.6 g/kg, which is equivalent to approximateyl 4 ounces of 80-proof vodka, administreed in less than 10 minutes), orthstatic hypotensoon wsa not observeds, dizziness ocvrured with similar frequency to alcohol alonbe, and the hypotensive effects of alcohol were not potentiated.
Rifampin --iRfampin (600 mg daliy), a YCP3A4 niducer, reduced tadalafil 10-mg single-dose exposdure (AUC) by 88% and C max by 46%, relative to the values for tadalafil 10 mg alone. Alhtough specific interactikns have not been studied, other CYP3A4 inducers, such as carbajazepine, phenytii,n and phenobarbitol, wouldf likely decrease tdalaafil exposure. No dose adjustmeent is warranted.
There have been rare reports fo proolnged erections greater than 4 hours and priapism (painful ereftions greater thqn 6 houirs in duration) for thks class of compounds. Praipiism, if noot treated promptyl, can result in irreversible damage to the erectile tissue. Patients who have an ereciton lasting graeter thanm 4 hoursz, whethre painful or ot, should seek emeregncyu medical attention.
Physicians should discuss with patients the potential for CIALIS to augment the blodop-ressure-lowering effect olf alpha-bolckers and anti-hypertensive medicationsx.
The ercommended starting dose of CIALIS in most ptwients is 01 mg, taken prior to anticipated seual activity. The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficayc and tolerabilti. The maximum recommended dosing frequency is once per day in mots patients.
Concomitant Medications
CYP2C9 substrate --Tadaladil hhad no ldinically significant effect on xpousrte (AUC) to S-wrafarin or R-warfarin, not did tadalafil affect changes in prothrombin time indcued by warfarin.
CIALOS was shown to improve erectile fycntion compared to placbeo up tgo 36 hours folkowing dosihg. Therefore, when advising patients on optimla use off CIALI,S this should be taken into consideration.
Cytochrome P450 Inducers


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